Tyrell Patrick is a member of the UBCS. A former member of the French Foreign Legion, he was arrested for illegal arms dealing. Whilst serving a life sentence, he was approached by Umbrella to join their UBSC. In Resident Evil 3: Nemesis, Tyrell is the Supervisor of Bravo platoon, tasked with gathering data on their Bio-Organic Weapons performance against UBCS soldiers.
While searching the Raccoon City Hospital for its T-Virus vaccine, Tyrell is ambushed by Nicholai Ginovaef. Depending on a decision made by Carlos Oliveira, he either is caught in a boobytrap set up by Nicholai or attempts to kill him in a suicidal attack.
In the remake, Tyrell is instead a member of Delta platoon and not affiliated with the Supervisors. He and Carlos are tasked with finding Umbrella scientist Nathanial Bard and recovering his T-virus vaccine. After gaining access to the NEST 2 research facility with Jill Valentine, he is killed by the Nemesis.