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Resident Evil 6 is a third-person shooter game developed and published by Capcom. A major installment in the Resident Evil series, Resident Evil 6 was released for the PlayStation 3 and Xbox 360 in October 2012, and for Microsoft Windows in March 2013. Players control Leon Kennedy, Chris Redfield, Jake Muller and Ada Wong as they confront the force behind a worldwide bio-terrorist attack. The story is centered around their four interwoven campaigns, and every campaign features a unique style in both tone and gameplay.

The game was conceptualized in 2009 and entered full development the following year under Resident Evil 4 producer Hiroyuki Kobayashi. It had a development staff of more than 600, making it Capcom's largest production. Resident Evil 6 received mixed reviews from critics, who criticised the interwoven campaigns and departure from the survival horror roots of the franchise. Despite these criticisms, the game sold over 10 million copies. It was re-released with all downloadable content for the PlayStation 4 and Xbox One in March 2016, and for the Nintendo Switch in October 2019. It was followed by Resident Evil 7: Biohazard (2017).


On 24 December 2012, Jake Muller (Troy Baker), son of late bio-terrorist Albert Wesker, flees local authorities during a bio-terrorist attack in Edonia. He partners with Division of Security Operations (DSO) agent and Raccoon City survivor Sherry Birkin (Eden Riegel) and learns that she is to extract him from the country to create a vaccine for the new C-virus. However, they are hunted by Ustanak, a hulking bio-weapon. Meanwhile, a Bio-terrorism Security Assessment Alliance (BSAA) strike team led by Chris Redfield (Roger Craig Smith) and Piers Nivans (Christopher Emerson) is deployed to combat the infected local populace. However, they are attacked by the leader of Neo-Umbrella, who refers to herself as Ada Wong (Courtenay Taylor); she kills most of the BSAA members, using a device that injects them with the C-virus, turning them into monsters, except Chris and Piers. Chris goes into a self-imposed exile, afflicted with post-traumatic amnesia. Meanwhile, Sherry and Jake's extraction by the BSAA is sabotaged, forcing them to crash into the mountains. They are captured by "Ada" for six months.

On 29 June 2013, US President Adam Benford (Michael Donovan) attempts to publicly reveal the truth behind the 1998 Raccoon City incident and the government's dealings with Umbrella, to end further bio-terrorist activity. However, the venue in the American town of Tall Oaks is hit by another attack, infecting the President; the sole survivors, DSO agent and Raccoon City survivor Leon Kennedy (Matthew Mercer) and United States Secret Service agent Helena Harper (Laura Bailey), are forced to kill him. The pair encounter the real Ada Wong (also Taylor), and Leon learns that National Security Advisor Derek Simmons (David Lodge) is affiliated with Neo-Umbrella and was responsible for the attack. Leon and Helena pursue Simmons into Lanshiang, China, while faking their deaths. Meanwhile, Jake and Sherry escape captivity in Lanshiang.

Chris returns to duty in the BSAA with Piers and a new team, arriving in a besieged Lanshiang. Chris recovers from his amnesia and seeks revenge against Ada, resulting in casualties for his squad. Chris and Piers confront Ada, until Leon intervenes. After being informed by Leon, Chris and Piers pursue "Ada" to an aircraft carrier, destroying cruise missiles laden with the C-virus. Leon, Helena, Sherry and Jake confront Simmons over his involvement with the outbreaks, where Sherry covertly hands Jake's medical data to Leon in case of their captivity. Leon and Helena corner Simmons, who has been infected by a J'avo, where he confesses to having killed the President to maintain national security. The two see off a mutated Simmons while Sherry and Jake are captured again. Attempting to leave the city, Leon and Helena are warned by Chris that a missile carrying the C-virus has been launched, and its detonation unleashes an outbreak in the city. Leon discloses Jake's real identity to Chris and has him rescue Jake and Sherry in a remote oil platform. With Ada's assistance, Leon and Helena kill Simmons.

On the oil platform, Chris and Piers head underground, freeing Jake and Sherry from captivity before preventing a large-scale attack by a gigantic bioweapon, Haos. Heavily wounded and in a desperate attempt to save Chris, Piers injects himself with the C-virus to help turn the tide of the battle. He defeats Haos before evacuating. Aware that the mutation will worsen, Piers sacrifices himself by pushing Chris to an escape pod, using his abilities to destroy the base. Meanwhile, Jake and Sherry escape the facility and kill Ustanak as they ride a rocket-powered lift to the surface.

The imposter Ada was a scientist named Carla Radames, who was forced to transform into Ada by Simmons. The real Ada was aiding Leon and Sherry while destroying the Neo-Umbrella lab in Lanshiang. Although presumed dead after being shot by one of Simmons' soldiers, Carla attempts a final attack against Ada, after having injected herself with a powerful dose of the C-virus, but is killed. Ada aids Leon and Helena in their battle with Simmons to kill him, and destroys the lab where her clone was developed before accepting a new assignment. Leon and Helena are cleared for duty; Chris remains with the BSAA in command of a new squad, overcoming his guilt; Sherry continues her duty as a DSO agent; and Jake starts a new life fighting B.O.W.s in an underdeveloped country with his identity covered up by the BSAA.