The Red Queen (played by Michaela Dicker, Megan Charpentier, Ave Merson-O'Brian and Ever Anderson) is a character of the Resident Evil film series. The Red Queen was created by the director Paul W. S. Anderson as a homage to 2001: A Space Odyssey's HAL 9000. She appears as the main antagonist in the first and the fifth film, and returns in the sixth film as a supporting character.
In Resident Evil, the Red Queen's holographic avatar was modeled on the daughter of Umbrella's head programmer. She monitors The Hive and the Spencer Mansion above. When the T-Virus was released, she sealed the exits and killed the Umbrella employees; she also released a gas that left Alice out cold with amnesia. When an Umbrella U.B.C.S. commando team is sent to investigate, she kills most of them with her defense systems. She warns against entering the Hive, but they shut her down. She is later forced to help the survivors find a way out, since her main circuit breakers were disabled to prevent rebooting. As the anti-virus has slimmer chance of working the longer one is infected, she demands Rain Ocampo be killed; however, she is shut down by Kaplan.
In an early draft of Resident Evil: Apocalypse, Angie Ashford, the daughter of T-virus' creator Dr. Charles Ashford, was to be revealed as the girl on whose appearance the Red Queen was based, and her father as the person that built the supercomputer that houses her. When the filmmakers realized they would need a large amount of flashback footage from the previous film to explain the connection to those in the audience that had not seen it, they decided to drop the idea, removing it from the canon. Nevertheless, some people have made the connection due to Angie's appearance and accent strongly evoking the Red Queen. The novelization of Resident Evil Extinction also explicitly states the connection.
In Resident Evil: Extinction, Alice encounters the White Queen, a sister artificial intelligence to the Red Queen, who similarly looks like a young girl, but dressed in white. The White Queen justifies her sister's actions, as the most logical path to contain the viral outbreak inside The Hive, from spreading. Nevertheless, she had decided to assist Alice by attempting to synthesis a cure to the outbreak after revealing her DNA to be potentially able to counteract the T-virus.
The Red Queen makes a reappearance in Resident Evil: Retribution, portrayed by child actress Megan Charpentier with another actress, Ave Merson-O'Brian, providing her voice. After the Raccoon City incident, she was reactivated and placed in control over Umbrella Prime, an underground laboratory in Kamchatka. By the time Retribution begins, she has assumed control over Umbrella itself and is waging war against the human race, including Albert Wesker, using various bioweapons.
The Red Queen reappears in Resident Evil: The Final Chapter, this time portrayed by Ever Gabo Anderson, the real daughter of Milla Jovovich (Alice) and Paul W. S. Anderson, the film's writer/director. In The Final Chapter, the Red Queen contacts Alice to warn her that the last human settlement will be destroyed in 48 hours. The Red Queen directs Alice back into the Hive to find a potent antivirus that will kill everything infected with the T-virus upon contact. The Red Queen is revealed to have been created based upon Alicia Marcus, the daughter of Umbrella co-founder James Marcus (with Ever Gabo portraying young Alicia in flashback footage). The Red Queen is willing to aid Alice as she has been programmed to protect human life, but is also unable to directly harm Umbrella forces due to another directive in her programming. During the final battle in the Hive, the Red Queen is able to aid Alice by dropping a blast door on Wesker after the adult Alicia Marcus (played by Jovovich, as all Alices are clones of Alicia) fires him. The Red Queen is later shut down by Dr. Alexander Isaacs, but first she taunts "Doctor Alexander Isaacs and the Umbrella High Command. You are all going to die down here", echoing her words to Alice and the soldiers in the first movie. When Isaacs is killed, the Red Queen reactivates herself and recalls the Umbrella forces sent to destroy the last human settlement, saving humanity. After the Hive is destroyed and the antivirus released, the Red Queen is revealed to have survived the Hive's destruction when she contacts Alice and explains how Alice survived the antivirus. The Red Queen displays Alicia Marcus' childhood memories for Alice, memories that Alicia had uploaded into the AI so that Alice would have them as well.
Although the character originated in the films, the Red Queen also appears in the 2007 game Resident Evil: The Umbrella Chronicles, voiced by Tara Platt. Her character appears as a database computer which provides information relating to the Arklay Incident and T-virus development. In the game's chapter "The Umbrella's End", the T-A.L.O.S. (Tyrant Armored Lethal Organic System) is monitored and controlled by the Red Queen. In the game, the Red Queen AI is self-aware and can take these measures based on its own judgment. At the end of the game, Wesker manages to procure all the data the Red Queen possessed for himself, and has it permanently erase itself and deactivate.