In Night Life, nearly two decades after battling the vampires of the Midnight Club in New York City, Davey is a marked man. He lives a quiet life in Los Angeles with the love of his life, Casey Thorne. The vampires he did not destroy back then have been hunting him ever since, eager to take their revenge - and now they have found him. For what he did to them, they are determined to make him pay with his last drop of blood. With the help of old friends and new allies, Davey and Casey must face the bloodthirsty nightmare of their past. This time, they may not have a future.