Karl Heisenberg is one of the four lords of Resident Evil Village and the owner of a factory located west of the Village.
Through experiments conducted on him with the Cadou, he is granted superhuman strength along with harnessing electromagnetism from the electric organs connected to his nervous system. Unlike the other lords, Heisenberg is more rebellious and actively plots to overthrow Mother Miranda for experimenting on him. He is the last of the village lords Ethan Winters faces, though he initially hands over Rose's torso willingly to help Ethan access his factory.
Claiming Miranda has been using him to eliminate the other Lords, Heisenberg proposes an alliance with Ethan to use his daughter to kill her. When he refuses, Heisenberg locks him into his factory to be killed by Soldat experiments. With help from Chris Redfield, Ethan battles a heavily cyber-mutated Heisenberg and kills him in a metal-polymer tank.