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Dr. Mittenhand, played by Guy Siner, is a character in the film Leprechaun 4: In Space.

Dr. Mittenhand is only part human due to a failed experiment. His body was largely replaced with robotic parts. He hopes to use Princess Zarina's regenerative DNA in order to repair his pwn body.

When Dr. Mittenhand acquires her DNA, the Leprechaun has added the remains of a blended scorpion and tarantula. The injection then turns Dr. Mittenhand into a monster. Mittenhand—now a grotesque monster calling himself "Mittenspider"—entangles Private Sticks in a giant web. Meanwhile, the other survivors confront the Leprechaun in the cargo bay, where they inadvertently cause him to transform into a giant after shooting him with Dr. Mittenhand's experimental growth ray. The ship's biological officer, Tina Reeves, escapes to the bridge and rescues Sticks by spraying Mittenhand with liquid nitrogen and shooting him, causing him to disintegrate.