Deborah Harper is a character in the video game Resident Evil 6.
Deborah is the younger sister of Helena Harper. In the past, Helena was known to be very protective towards Deborah, having wounded Deborah's abusive ex-boyfriend. In Resident Evil 6, the two sisters were held as hostages by Derek C. Simmons in the secret lab underneath the Tall Oaks Cathedral. Helena tried her best to keep a terrified Deborah calm and assures her. Helena offered herself to Simmons in exchange for her sister, but her pleas did nothing and Deborah was dragged away.
Deborah was later taken to the catacombs of the cathedral, and was injected with C-Virus; however, as she showed no signs of mutation, Deborah was left to die. After Helena and Leon Kennedy rescue Deborah, they soon arrive at the lower levels of the catacombs, where Deborah becomes very ill before bursting into flames; a goo then hardens into a cocoon around her. As the lower levels then begin to crumble, Deborah emerges with spider-like appendages on her back. Despite Helena's pleas not to harm her sister, Ada Wong reminds her that Deborah has to be killed or else they will die.
After the battle, Helena grabs Deborah as she slips and falls over a pit. She then begs for forgiveness, saying she will avenge her sister after she and Leon kill Simmons, and releases Deborah as she falls to her death into the darkness below. At the end of Leon and Helena's campaign, Helena visits Deborah's grave at a cemetery.