Bride of Re-Animator is a 1990 American comedy horror film produced and directed by Brian Yuzna and written by Yuzna, Rick Fry, and Woody Keith. It is a sequel to the 1985 film Re-Animator and the second entry in the Re-Animator film series. Like its predecessor, it is loosely based on the serialized story "Herbert West–Reanimator" by H. P. Lovecraft.
The plot of Bride of Re-Animator roughly follows episodes "V. The Horror from the Shadows" and "VI. The Tomb-Legions" of the Lovecraft story, and follows doctors Herbert West and Dan Cain as they attempt to create a living woman from dead tissue. The film stars Bruce Abbott, Claude Earl Jones, Fabiana Udenio, David Gale, and Kathleen Kinmont, with Jeffrey Combs as Herbert West. It was followed by a sequel, Beyond Re-Animator, released in 2003.
Eight months after the events of Re-Animator, doctors Herbert West and Dan Cain are working as medics in the middle of a bloody Peruvian civil war. In the chaos of battle and with plenty of casualties to work on, they are free to experiment with West's re-animation reagent. When their medical tent is stormed by the enemy troops, West and Cain return home to Arkham, Massachusetts. There, they resume their former jobs as doctors at Miskatonic University Hospital, and West returns to the basement laboratory of Cain's house to continue his research.
Using parts pilfered from both the hospital's morgue and from a cemetery located next door, West discovers that his reagent can re-animate body parts by themselves. He becomes determined to create an entire living person from disparate body parts. West discovers the heart of Megan Halsey, Cain's fiancée, in the hospital morgue. With the promise to use her heart to re-animate a new Megan, West convinces Cain to help him with his project. Also stored in the morgue is the rest of the evidence from the previous "Miskatonic Massacre". Inside, pathologist Dr. Wilbur Graves discovers a vial of West's reagent and the severed head of Dr. Carl Hill. Using the reagent, he re-animates Hill's head.
Meanwhile, police officer Lt. Leslie Chapham begins investigating West and Cain. He bears a grudge against the pair, as they were the only unaffected survivors of the Miskatonic Massacre; the dead body of Chapham's wife was re-animated into a crazed zombie during the incident (it is implied later in the film that he caused her death). Chapham suspects West and Cain were responsible. When he stops by their house to question them, he discovers West's corpse-filled lab and the two get into a confrontation. A fight ensues and West kills Chapham by means of cloth treated with a chemical which causes cardiac arrest when inhaled (a product of West's research into obtaining the freshest possible corpses for his experiments). West then re-animates the police officer with the intention of covering up his crime. Chapham violently wanders out of the house and into the cemetery next door.
Hill, who bears a grudge against West, uses psychic powers to command Chapham to force Dr. Graves to stitch bat wings onto his neck, giving him back his mobility. He also extends his mental control to all of the zombie survivors of the Miskatonic Massacre.
When one of Cain's patients, Gloria, dies, West collects the last piece he needs for his creation: her head. With a complete body stitched and wired together, West and Cain inject the re-animation reagent into Meg's heart. While waiting for the reagent to take effect, a package is delivered to their house. West retrieves and opens it. From inside, Hill's winged head flies out. Simultaneously, the zombies Hill controls break into the house. West retreats back to the basement lab, where his creation, the Bride, has awoken.
A catfight breaks out between the Bride and Cain's current girlfriend, Italian journalist Francesca Danelli, whom he met in Peru. Cain rejects the Bride's love and sides with Francesca. Heart-broken, the Bride rips Megan's heart out of her own chest and then falls to pieces. West diagnoses this as tissue rejection.
Hill and his zombies force West, Cain and Francesca to retreat through the wall of the lab and into a crypt in the neighboring cemetery. Inside, all of West's prior test subjects arise and make their way towards him, stopping only when Herbert commands them to. The unstable crypt begins to collapse, trapping Hill, West and the zombies. Cain and Francesca manage to escape the debris and claw their way to the surface of the cemetery together. Hill, stuck in the debris, laughs manically, while Megan's heart, still in the hand of the Bride, stops beating.