Brian Irons is a character in the game Resident Evil 2.
Irons is the Police Chief of the RPD. He is secretly bribed by Umbrella to cover up the T-Virus outbreak in the Arklay laboratories and their experiments with the G-Virus. During the Raccoon City outbreak, Irons goes insane and begins killing people in the department building indiscriminately, including Mayor Warren's daughter Katherine. Irons is encountered several times by Claire Redfield, who gradually learns of his alliance with Dr. William Birkin and Umbrella. He is eventually killed by a mutated Birkin.
In the game's remake, Irons kidnaps Sherry Birkin and tries to use her pendant to access the NEST facility. It is also revealed that he is also the director of an orphanage used to supply Umbrella with human test subjects, where he holds her until he can retrieve her pendant from Claire. Irons chases Sherry as she attempts to escape, but is eventually attacked and implanted with an G-embryo. He dies when the creature erupts from his body just as Claire arrives to confront him. Irons also appears in Resident Evil: The Darkside Chronicles, though his role is greatly downplayed to a brief confrontation with Leon Kennedy and Claire.
In the reboot film Resident Evil: Welcome to Raccoon City (2021), Irons will be played by Donal Logue.