Annette Birkin is a supporting character in Resident Evil 2.
She is involved in Bio Organic Weapon research at Umbrella, working with her husband William to create the G-Virus. During the Raccoon City outbreak, Annette works to stop Umbrella's experiments from spreading further into the city.
She leaves their daughter Sherry at the Raccoon Police Department with a pendant containing the virus, hoping Irons can protect her. During the game's events, Annette helps Claire Redfield cure Sherry's G-virus infection and reveals Ada's true motives to Leon Kennedy.
She is fatally injured, forcing them to leave her behind. Annette appears in the game's remake, maintaining the same role as in the original game, and its retelling in Resident Evil: The Darkside Chronicles.