The main antagonist of Resident Evil: Revelations 2, an Umbrella researcher who quotes Franz Kafka and developed the T-Phobos Virus, which causes those infected to mutate when overcome with fear. Alex is the only other surviving participant of the Wesker project besides her “brother” Albert Wesker despite lacking Albert's heightened abilities. Alex uses her position in Umbrella to establish a facility on the impoverish Sejm Island, kickstarting an economic recovery while exploiting the residents to be her test subjects for T-Phobos Project that Spencer assigned her as a means for him to cheat death. But Alex is spurred by her failing health to instead develop a method to transplant a digital copy of her mind into a host body able to resist fear. Hastening her work after learning of Spencer and Albert's deaths, Alex exploits Neil Fisher with the Uroboros virus she was refining to provide her with candidates from TerraSave, with only Claire Redfield and Moira Burton the sole survivors of her experiments.
Alex also captures Natalia Korda as her ideal host, disposing of Fisher before proceeding with her experiment before committing suicide with the expectation to awaken as Natalia within six months. But she is instead mutated by the T-Phobos at the last second from fearing her own demise, suffering an existential crisis with the maddened resolve to kill Natalia before her copy could manifest by releasing the Uroboros virus on the island as Barry arrived. After infecting herself with the Uroboros, Alex is killed during the BSAA's assault on the island. Regardless of Alex's death, her copy starts manifesting as depicted in the bonus episode "Little Miss" and the game's epilogue.